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Keefe Sencen (pronounced Keef Sense-in) is the deuteragonist in the Keeper of the Lost Cities series. He is a member of the Black Swan and a former member of the Neverseen. He joined the Neverseen as a double agent in an attempt to infiltrate it and tear it down from the inside, as well as to sneak information to the Black Swan.

Keefe is the only child of Lord Cassius Sencen and Lady Gisela Minette Sencen, who is a part of the Neverseen. He is best friends with Fitz Vacker and has shown that he's always wished he was a Vacker — to the point of him seeing the Vackers as his family, and as such spends a lot of time with them. He has family issues (even claiming the role of troublemaker with Daddy Issues, also being grumpy about Tam Song's claim to the title as well), as his father was both verbally and emotionally abusive, while his mother, a member of the Neverseen before Keefe was even born, treats him as a pawn in her overarching plan after lying to him for years. His mother, however, has shown fake kindness to him multiple times in the books. Keefe still shows how his mother didn't say anything when Lord Cassius abused Keefe. In Exile, he admits to Sophie that he often hides behind his jokes and teasing and he uses them to pretend everything is okay, although deep down it's not; making jokes and teasing people are his coping mechanisms.

Some interpret the name Keefe as meaning noble, gentle, handsome, and cherished, although there are many meanings for this name throughout different cultures. For example, in Gaelic, the name translates as "male descendant" or "related by blood", often used for the oldest child in a family. His middle name on his registry pendant record is redacted, although he dubs it "I'm-not-your-legacy-boy". This may show that either he doesn't like his middle name, he's embarrassed about it, or it reminds him too much of painful memories.

Keefe has a crush on Sophie and as of Book 9: Stellarlune she has confirmed to return his feelings and the two are currently in an in-between stage of friends and more-than-friends.